Formulation and Evaluation of the Antidiabetic, Hypolipidemic and Antioxidant Potential of the Tablets of Arbortristoside-A from the Seeds of Nyctanthes arbortristis Linn.

Abstract: Aim: Literature shows the traditional as well scientific proven medicinal importance of Nyctanthes arbortristis Linn. In it was aimed at to formulate and screen antidiabetic, hypolipidemic antioxidant properties tablets arbortristoside-A obtained from N. seeds. Materials Methods: Arbortristoside-A chemically isolated seeds’ ethanolic extract arbortristis. The property screened in-vitro by help DPPH (2,2-diphenyl-1- picrylhydrazyl) methodology. granules arbortristocide-A with suitable excipients were prepared wet granulation method. rotating punch tablet machine subjected standard evaluation process. Its antidiabetic evaluated using streptozotocin-induced diabetic wistar rats either sex. This study also included a serum biochemical assays pancreatic hepatic histopathological modification. Results: Daily oral treatment glibenclamide (10 mg/kg) for three weeks reduced plasma glucose, cholesterol, triglycerides, AST ALT levels significantly whereas improvement in HDL-cholesterol level observed (p<0.01) that control animals. Significant recovery pancreas liver administration which supported its significant activity. Conclusion: Present results indicated have prominent effect overall management diabetes mainly higher dose (75 due antilipidemic properties. Key words: Antioxidant, tablet, arbostristoside-A, DPPH, streptozotocin, histopathology.